By S. Eva Singletary, Geoffrey L. Robb
Edited by way of awesome leaders within the box of breast sickness (Dr. Singletary chairs the Breast melanoma Committee for the yankee university of Surgeons), this ebook deals first-hand recommendation on prevention, prognosis, remedy and reconstruction by means of well-known experts. The paintings good points the non-public therapy protocols of the head physicians and surgeons focusing on breast affliction. stipulations lined comprise benign and malignant tumors, endocrine and aggravating issues, and adolescent and grownup difficulties in either men and women. Key positive aspects: - comprises authoritative suggestion according to the scientific adventure of famous investigators - offers an exceptional review of breast affliction, beginning with breast screening, and advancing to themes akin to silicone autoimmune sickness and breast reconstruction innovations - Takes a well-rounded method of sufferer therapy, with articles on psychosocial difficulties regarding breast melanoma, and the follow-up care of the breast melanoma sufferer - followed via a CD-ROM with the full textual content and illustrations of the e-book, in totally searchable PDF records viewers: scholars and practitioners in surgical procedure, plastic and reconstructive surgical procedure, oncology, and gynecology.
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Extra info for Advance Therapy of Breast Disease
18. Statement of the American Society of Clinical Oncology: genetic testing for cancer susceptibility. J C h Oncol 1996;14:1730-6. 19. Couch FJ, Farid LM, Deshano ML, et al. BRCA-2 germline mutations in male breast cancer cases and breast cancer families. Nat Genet 1996;13:123-5. 5. Bondy ML, Lustbader ED, Halabi S, et al. Validation of a breast cancer risk assessment model in women with a positive family history. J Natl Cancer Inst 1996;86:620-5. 20. Ford D, Easton DF, Stratton M, et al. Genetic heterogeneity and penetrance analysis of the BRCA- 1 and BRCA-2 genes in breast cancer families.
21 Genetic models have suggested that up to 36% of breast cancers diagnosed in women before age 30 will have a strong hereditary component. 24The discrepancy raises the question of additional breast cancer susceptibility genes underlying early onset breast cancer. Another feature useful in the estimation of mutation carrier status is ethnicity. Certain mutations are known to cluster among individuals of specific heritage. “Founder” mutations are specific genetic alterations that occur at increased frequency in a population originating with a small ancestral group.
Tamoxifen does have potentially serious side effects, and its observed benefits have been observed only during its use to date. Further evaluation of this approach to prevention is surely necessary in the high risk cohort. 48Additional data on oral contraceptives are critical for younger women from high-risk families. Conclusion The past decade has brought an explosion in genetic information to the care of women at risk for breast and related cancers. Most professional societies and cancer genetics experts recommend that women considering genetic testing for breast cancer susceptibility receive education and counseling so that they can make informed decisions about testing, and about the implications of genetic information for Genetic Counseling of the High-Risk Patient / 25 themselves and their families.
Advance Therapy of Breast Disease by S. Eva Singletary, Geoffrey L. Robb